In VitroEffect of Lithium Chloride on Interleukin-15 Production by Monocytes from Breast Cancer Patients
| Autor: | Rosaria Alba Merendino, Sebastiano Gangemi, Antonella Ruello, E. Losi, Adriana Arena, A. Valenti, A. Bene, F. Purello D’Ambrosio |
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| Rok vydání: | 2000 |
| Předmět: |
Lithium Chloride
Lipopolysaccharides Interleukin-15 medicine.medical_treatment Breast Neoplasms Biology Monocytes chemistry.chemical_compound Breast cancer medicine Humans Pharmacology (medical) Cells Cultured Aged Neoplasm Staging Pharmacology Lymphokine-activated killer cell Monocyte Cancer Middle Aged medicine.disease Metastatic breast cancer Infectious Diseases Cytokine medicine.anatomical_structure Oncology chemistry Interleukin 15 Immunology Cancer research Lithium chloride Female |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1973-9478 1120-009X |
| Popis: | Lithium salt compounds are used to limit the degree and duration of neu-tropenia in patients receiving chemotherapy for cancer. Interleukin-15 (IL-15) is a cytokine which possesses promoting activities on hematopoiesis and is also involved in antitumor response, activating NK, CTL and LAK cells. In this study we analyzed IL-15 production by monocyte cultures treated with lithium chloride (LiCl). Monocytes were obtained from patients affected by non-metastatic and metastatic breast cancer. LiCl treatment induced IL-15 production by monocytes mainly from non-metastatic patients. Combined lipopolysacchar-ide/LiCl treatment of monocyte cultures up-regulated IL-15 release compared to those treated with LPS alone (p |
| Databáze: | OpenAIRE |
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