Supplemental Figures 1-10, Supplemental Tables 1 and 2 from Mast Cell–Dependent CD8+ T-cell Recruitment Mediates Immune Surveillance of Intestinal Tumors in ApcMin/+ Mice

Autor: Bodduluri Haribabu, Venkatakrishna R. Jala, Alberto Mantovani, Massimo Locati, Sergio Lira, Thomas C. Mitchell, Paula M. Chilton, Shuchismita R. Satpathy, Elangovan Krishnan, Paramahamsa Maturu, Steven Mathis, Sobha R. Bodduluri
Rok vydání: 2023
Popis: S1: Unaltered tumor burden in colons of ACKR2-/-ApcMin/+ mice. S2: Delayed onset of tumor development in the small intestine of ACKR2-/-ApcMin/+ mice. S3. Decreased inflammatory markers in the distal intestine tumors of ACKR2-/-ApcMin/+ mice. S4. Elevated mast cell infiltration into microadenomas in ACKR2-/-ApcMin/+ mice. S5. Identification of BMMC. S6. Relative expression levels of chemokine receptors in BMMC. S7. Dinitrophenyl (DNP) induced calcium release in BMMC. S8. Analysis of CCR2 and CCR5 expression in immune cells from ACKR2-/- mice. S9. Uptake and MHC-1 mediated presentation of peptide antigens by mast cells. S10. Mast cell infiltration into ACKR2-/- tumors is not dependent on T cells. Supplemental Table 1: List of primers used for mouse genotyping. Supplemental Table 2: List of mouse Real Time PCR primer sequences.
Databáze: OpenAIRE