Reduction of skin innervation is associated with a severe fibromyalgia phenotype
| Autor: | Claudia Sommer, Johanna Frank, Aikaterini Papagianni, Bodo Warrings, Alexander Klitsch, Jordi Serra, Nadine Saffer, Nurcan Üçeyler, Daniel Kampik, Stefan Unterecker, Rayaz A. Malik, Dimitar Evdokimov, Caren Meyer Zu Altenschildesche |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Fibromyalgia Urology Neurological examination Nerve fiber Anxiety Nerve conduction velocity Cornea Young Adult 03 medical and health sciences Nerve Fibers 0302 clinical medicine Biopsy medicine Humans ddc:610 Evoked Potentials Aged Pain Measurement Skin Depressive Disorder Major medicine.diagnostic_test business.industry Case-control study Microneurography Middle Aged medicine.disease Phenotype 030104 developmental biology medicine.anatomical_structure Neurology Case-Control Studies Sensory Thresholds Major depressive disorder Female Neurology (clinical) Atrophy Chronic Pain business 030217 neurology & neurosurgery |
| Zdroj: | Annals of Neurology. 86:504-516 |
| ISSN: | 1531-8249 0364-5134 |
| Popis: | OBJECTIVE To assess patterns and impact of small nerve fiber dysfunction and pathology in patients with fibromyalgia syndrome (FMS). METHODS One hundred seventeen women with FMS underwent neurological examination, questionnaire assessment, neurophysiology assessment, and small fiber tests: skin punch biopsy, corneal confocal microscopy, microneurography, quantitative sensory testing including C-tactile afferents, and pain-related evoked potentials. Data were compared with those of women with major depressive disorder and chronic widespread pain (MD-P) and healthy women. RESULTS Intraepidermal nerve fiber density (IENFD) was reduced at different biopsy sites in 63% of FMS patients (MD-P: 10%, controls: 18%; p |
| Databáze: | OpenAIRE |
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