Concomitant Acute Tubular Necrosis and Acute Interstitial Nephritis Induced by Tipifarnib in a Patient with Squamous Cell Carcinoma of the Lung
| Autor: | Amir Shabaka, Gema Fernández-Juárez, Xabier Mielgo-Rubio, Sara Gimenez-Moyano, Carmen Guerrero-Marquez, Paula Martinez de la Cruz |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Lung Neoplasms Renal function Antineoplastic Agents Quinolones 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Biopsy medicine Humans 030212 general & internal medicine Acute tubular necrosis Aged Kidney Squamous-cell carcinoma of the lung medicine.diagnostic_test urogenital system business.industry Acute kidney injury General Medicine medicine.disease medicine.anatomical_structure Concomitant Carcinoma Squamous Cell Nephritis Interstitial Kidney Cortex Necrosis Tipifarnib business medicine.drug |
| Zdroj: | The American Journal of the Medical Sciences. 362:99-102 |
| ISSN: | 0002-9629 |
| Popis: | Tipifarnib is a novel targeted treatment for hematologic malignancies that is being recently studied for the treatment of advanced solid organ tumors with HRAS mutations. There have been scarce reports on kidney adverse events in initial phase I and II trials. We present a case of acute kidney injury in a patient that had started treatment with tipifarnib for advanced squamous cell carcinoma of the lung. Kidney biopsy revealed acute tubular necrosis together with acute interstitial nephritis. Tipifarnib was discontinued and the patient was started with high-dose corticosteroids with an early taper completing a five-week steroid course, with full recovery of kidney function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|