Chemico-calorimetric analysis of amorphous granules manufactured via continuous granulation process
| Autor: | Saeid Rajabnezhad, Mridul Majumder, Ali Nokhodchi, Mohammed Maniruzzaman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Materials science
Solution calorimetry Drug Compounding Pharmaceutical Science chemistry.chemical_element Magnesium Compounds 02 engineering and technology Calorimetry 030226 pharmacology & pharmacy law.invention Excipients 03 medical and health sciences Granulation 0302 clinical medicine Adsorption Optical microscope law Twin screw granulations Particle Size Aluminum Compounds Magnesium Silicates Sorption 021001 nanoscience & nanotechnology Amorphous solid Drug Liberation Chemical engineering chemistry Granules Solubility Amorphous Original Article 0210 nano-technology DVS Porosity Powder diffraction |
| Zdroj: | Drug Delivery and Translational Research |
| ISSN: | 2190-3948 2190-393X |
| Popis: | The current study explores the first case of the implementation of solution calorimetry (SolCal) in order to determine the amorphous content of crystalline benzoyl-methoxy-methylindol-acetic acid (BMA)—a model poorly soluble drug, in the amorphous granules prepared via single-step continuous twin-screw dry granulations (TSG). Amorphous magnesium aluminometasilicate (Neusilin®) (US2) was used as a novel inorganic carrier via a TwinLab 10 mm twin-screw extruder. The BMA/US2 blends were processed at 180 °C and varying drug: carrier ratios of 1:4, 1:2.5 and 1:1 (w/w). Physico-chemical characterisation conducted via SEM, DSC and XRPD showed amorphous state of the drug in all granulated formulations. Reverse optical microscopy revealed a meso-porous structure of US2 in which the drug particles are adsorbed and/or entrapped within the porous network of the carrier. This phenomenon can be the underlying reason for the increase of the amorphous content in the extruded granules. Solution calorimetry (SolCal) study revealed amorphous content of the drug in all formulations quite precisely, whereas the dynamic vapour sorption (DVS) analysis complemented the results from SolCal. Furthermore, an attempt has been made for the first time to interrelate the findings from the SolCal to that of the release of the drug from the amorphous granules. It can be concluded that SolCal can be used as a novel technique to precisely quantify and interrelate the amorphous content to its physico-chemical performances such as drug release from the granulated formulations processed via TSG. |
| Databáze: | OpenAIRE |
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