Electroacupuncture Stimulation at CV12 Inhibits Gastric Motility via TRPV1 Receptor
| Autor: | Ya-Li Wang, Bin-bin Ren, Youbing Xia, Jing-Feng Jiang, Xin Cao, Hong Feng, Bin Xu, Zhi Yu |
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| Rok vydání: | 2013 |
| Předmět: |
Article Subject
Electroacupuncture business.industry medicine.medical_treatment TRPV1 Antagonist Gastric motility Motility Stimulation lcsh:Other systems of medicine Pharmacology lcsh:RZ201-999 chemistry.chemical_compound Complementary and alternative medicine chemistry Knockout mouse medicine Capsazepine business Research Article |
| Zdroj: | Evidence-based Complementary and Alternative Medicine : eCAM Evidence-Based Complementary and Alternative Medicine, Vol 2013 (2013) |
| ISSN: | 1741-4288 1741-427X |
| DOI: | 10.1155/2013/294789 |
| Popis: | Gastric dysmotility is one of the major pathophysiological factors in functional gastrointestinal disorders. Acupuncture, as one of the alternative approaches, is efficacious in the treatment of gastrointestinal motility disorders; however, the mechanism underlying its action is unclear. In the present study, we used both capsazepine, a TRPV1 antagonist, and TRPV1 knockout mice. Animals were divided into wild-type group (WT), capsazepine injection group (CZP, 0.5 mg/kg, i.p.), and TRPV1 knockout mice group (TRPV1−/−). Each of these three groups was divided into three subgroups, which were subjected to EA stimulation at acupoint Zhongwan (CV12) at a different intensity (1, 2, or 4 mA). We demonstrated that electroacupuncture at Zhongwan (CV12) markedly inhibited gastric motility at 2 and 4 mA in an intensity-dependent manner in wild-type mice. The inhibitory effect was also observed in capsazepine-injected and TRPV1−/−mice but was no longer intensity dependent, indicating that TRPV1 is partially involved in the electroacupuncture-mediated modulation of gastric motility. |
| Databáze: | OpenAIRE |
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