Arbutus unedo L., (Ericaceae) inhibits intestinal glucose absorption and improves glucose tolerance in rodents
| Autor: | Hanae Naceiri Mrabti, Bruno Eto, Jehan-François Desjeux, Ferdinand Kouoh Elombo, Yahia Cherrah, François Massako Mayuk, Bernard Gressier, Moulay El Abbes Faouzi, Hanane Makrane, Siegfried Didier Dibong, Nicolas Limas-Nzouzi |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Plant Roots Intestinal absorption Rats Sprague-Dawley 03 medical and health sciences Inhibitory Concentration 50 Mice 0302 clinical medicine Oral administration In vivo Diabetes mellitus Drug Discovery medicine Animals Hypoglycemic Agents 030304 developmental biology Arbutus unedo Pharmacology 0303 health sciences biology Traditional medicine Dose-Response Relationship Drug Chemistry Plant Extracts Glucose transporter Glucose Tolerance Test biology.organism_classification medicine.disease Metformin Rats Mice Inbred C57BL Morocco Glucose Intestinal Absorption 030220 oncology & carcinogenesis visual_art visual_art.visual_art_medium Bark Ericaceae Female Medicine Traditional medicine.drug |
| Zdroj: | Journal of ethnopharmacology. 235 |
| ISSN: | 1872-7573 |
| Popis: | Ethnopharmacological relevance Arbutus unedo L., (Ericaceae) is one of the most traditional plants commonly used to treat diabetes in people living in Eastern Morocco region particularly in Taza and Beni Mellal. Aim of the study The aim of the study was to find if there is a scientific support to the ethnopharmacological relevance use of Arbutus unedo L., roots bark (AU) to treat diabetes. Materials and methods We studied the effects of crude aqueous extract of AU on intestinal glucose absorption using short-circuit current technique in vitro and oral glucose tolerance test in vivo. Results The aqueous extract of AU (10 µg/mL to 1 mg/mL) induced concentration-dependent inhibition of sodium-dependent glucose transport across isolated mouse jejunum. The maximal inhibition was obtained with 1 mg/mL, which exhibited more than 80% of the Phloridzin inhibition with an IC50 close to 216 µg/mL. A 6-week AU ingestion (2 g/(kg day)), improved oral glucose tolerance as efficiently as metformin (300 mg/(kg day)). Arbutus unedo L. and metformin also reduced body weight. Conclusions Arbutus unedo L. roots bark aqueous extract directly inhibited the electrogenic intestinal absorption of glucose in vitro. In addition it improved oral glucose tolerance and lowered body weight in rats after chronic oral administration in vivo. These results add a scientific support to the ethnopharmacological relevance use of Arbutus unedo L. roots bark to treat diabetes. |
| Databáze: | OpenAIRE |
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