Reduced circulating B cells and plasma IgM levels are associated with decreased survival in sepsis - A meta-analysis
| Autor: | Sarah L. Maier, Maximilian Brunner, Christian Krautz, Evangelos J. Giamarellos-Bourboulis, Georg F. Weber, Robert Grützmann, Apostolos Armaganidis, Charalambos Gogos, Frank Kunath, Melanie Langheinrich |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Critical Care Inflammation Critical Care and Intensive Care Medicine Gastroenterology Sepsis 03 medical and health sciences 0302 clinical medicine Web of knowledge Predictive Value of Tests Internal medicine medicine Humans Prospective Studies Prospective cohort study B cell B-Lymphocytes biology business.industry 030208 emergency & critical care medicine medicine.disease Confidence interval 030104 developmental biology medicine.anatomical_structure Immunoglobulin M Meta-analysis biology.protein Antibody medicine.symptom business Biomarkers |
| Zdroj: | Journal of Critical Care. 45:71-75 |
| ISSN: | 0883-9441 4201-6053 |
| Popis: | Background B cell function and antibody production are crucial factors in host protection during inflammation. We aimed to synthesize the available evidence on the association between the reduction of circulating B cells and plasma immunoglobulin (IgM) levels and decreased survival during sepsis. Methods We performed a systematic search in PubMed, Embase, ISI Web of Knowledge, Cochrane Central Register of Controlled Trials, BioMed Central, and Science Direct. We selected studies with data on circulating B cells and plasma IgM levels within the initial 24 h after sepsis onset. Results In total nine studies (n = 992 patients) were identified. Circulating B cells were reduced in septic patients as compared to non-septic patients (mean difference [MD] −88.2 cells/μl; 95% confidence interval [CI] −148.6–−27.9). Sepsis non-survivors showed a significant reduction of circulating B cells and IgM levels compared to sepsis survivors (MD −77.1 cells/μl; 95% CI −111.4–−42.7 and MD −20.9 mg/dl; 95% CI −33.8–−8.0, respectively). Conclusions Our results suggest that a reduction of circulating B cells and IgM levels at sepsis onset are associated with decreased sepsis survival. However, due to methodological limitations and the risk of bias, we need further prospective studies to confirm this association. Registration The protocol was registered (PROSPERO 2016:CRD42016053184). |
| Databáze: | OpenAIRE |
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