Chronic urticaria and thyroid autoimmunity markers

Autor: Laimute Jurgauskiene, Anzelika Chomiciene, Audra Blaziene
Rok vydání: 2012
Předmět:
Zdroj: Central European journal of medicine, Warsaw : Versita, 2012, vol. 7, no 6, p. 736-741
Open Medicine, Vol 7, Iss 6, Pp 736-741 (2012)
ISSN: 2391-5463
1895-1058
DOI: 10.2478/s11536-012-0074-0
Popis: The association of chronic urticaria and autoimmune thyroid disease has been well recognized. Some authors observed relationship between thyroid autoimmunity and chronic autoimmune urticaria. The primary objective was to evaluate thyroid autoimmunity and thyroid function in chronic urticaria. Secondary objective was to correlate results of antibodies to thyroid peroxidase and markers of autoimmune urticaria (autologous serum skin test and CD63 expression). 128 patients with chronic urticaria were evaluated for antibodies to thyroid peroxidase, autologous serum skin test and donor basophil CD63 expression induced by patients sera. Thyroid-stimulating hormone was performed in all patients with elevated antibodies to thyroid peroxidase and 48 patients with normal level of antibodies. Antibodies to thyroid peroxidase were elevated in 25.0% patients. Thyroid function was abnormal in 28.1% patients with elevated antibodies to thyroid peroxidase and 8.3% patients with normal antibodies level. We did not find the relationship between thyroid antibodies and markers of autoimmune urticaria (autologous serum skin test and CD63 expression). Chronic urticaria was frequently associated with thyroid autoimmunity. We did not observe significant relationship between chronic autoimmune urticaria and thyroid autoimmunity and we suggest these are tangential, parallel autoimmune events.
Databáze: OpenAIRE
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