Hydroxycamptothecin liposomes based on thermal and magnetic dual-responsive system: preparation, in vitro and in vivo antitumor activity, microdialysis-based tumor pharmacokinetics
| Autor: | Hai-Mei Zhu, Jin-Hui Gu, Yi Xie, Jia-Jun Ling, Bo Xie |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Microdialysis Carcinoma Hepatocellular Pharmaceutical Science 02 engineering and technology Pharmacology 010402 general chemistry 01 natural sciences Rats Sprague-Dawley Magnetics Mice Drug Delivery Systems Pharmacokinetics In vivo Cell Line Tumor medicine Animals Humans Cytotoxicity Liposome Drug Carriers Chemistry Liver Neoplasms Temperature 021001 nanoscience & nanotechnology Antineoplastic Agents Phytogenic In vitro 0104 chemical sciences Rats Liposomes Camptothecin 0210 nano-technology Drug carrier medicine.drug |
| Zdroj: | Journal of drug targeting. 26(4) |
| ISSN: | 1029-2330 |
| Popis: | Due to the absence of lactone form of hydroxycamptothecin, the commercially available hydroxycamptothecin injection exhibits inefficient therapeutic effects. In this study, we constructed a novel delivery system (thermosensitive magnetic liposomes) that protects lactone form of hydroxycamptothecin from blood or water. After hydroxycamptothecin was loaded into the thermosensitive magnetic liposome (HCPT/TML), its in vitro and in vivo antitumor activity and microdialysis-based tumour pharmacokinetics were determined. The results demonstrated that HCPT/TMLs possessed favourable physicochemical features and significant cytotoxicity against the Huh-7 cells in vitro. In the in vivo antitumor study and tumour pharmacokinetics, HCPT/TMLs displayed effective targeting delivery and antitumor effects, which corresponded to the determined hydroxycamptothecin concentration in tumour tissue. In conclusion, this thermal and magnetic dual-responsive system can efficiently deliver hydroxycamptothecin to tumour tissue and has great potential application in cancer treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|