Opposite Roles of Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Transcriptional Regulation of Plant Immunity
Autor: | Yuelin Zhang, Yujun Peng, Kevin Ao, Yaxi Zhang, Xin Li, Yuli Ding, Tongjun Sun |
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Rok vydání: | 2018 |
Předmět: |
0106 biological sciences
0301 basic medicine Genotype Ubiquitin-Protein Ligases Arabidopsis Gene Expression Biology 01 natural sciences General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Plant Growth Regulators Gene Expression Regulation Plant Gene expression Transcriptional regulation Plant Immunity Receptor Transcription factor Plant Diseases Regulation of gene expression Arabidopsis Proteins Gene Expression Profiling fungi NPR1 biology.organism_classification Cell biology 030104 developmental biology Mutation Seeds Signal transduction Salicylic Acid Signal Transduction Transcription Factors 010606 plant biology & botany |
Zdroj: | Cell. 173:1454-1467.e15 |
ISSN: | 0092-8674 |
Popis: | Salicylic acid (SA) is a plant defense hormone required for immunity. Arabidopsis NPR1 and NPR3/NPR4 were previously shown to bind SA and all three proteins were proposed as SA receptors. NPR1 functions as a transcriptional co-activator, whereas NPR3/NPR4 were suggested to function as E3 ligases that promote NPR1 degradation. Here we report that NPR3/NPR4 function as transcriptional co-repressors and SA inhibits their activities to promote the expression of downstream immune regulators. npr4-4D, a gain-of-function npr4 allele that renders NPR4 unable to bind SA, constitutively represses SA-induced immune responses. In contrast, the equivalent mutation in NPR1 abolishes its ability to bind SA and promote SA-induced defense gene expression. Further analysis revealed that NPR3/NPR4 and NPR1 function independently to regulate SA-induced immune responses. Our study indicates that both NPR1 and NPR3/NPR4 are bona fide SA receptors, but play opposite roles in transcriptional regulation of SA-induced defense gene expression. |
Databáze: | OpenAIRE |
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