DNA vaccines that express the MPER of HIV-1 gp41 elicit different antibodies depending upon their transmembrane and cytoplasmic domains

Autor:	Ted M. Ross, Jamie K. Scott, Naveed Gulzar, Kristina-Ana Klaric, Shixia Wang, Shan Lu
Rok vydání:	2012
Předmět:	lcsh:Immunologic diseases. Allergy biology business.industry Gp41 Bioinformatics Virology Epitope Transmembrane protein DNA vaccination Infectious Diseases Protein structure Cytoplasm Poster Presentation biology.protein Medicine Antibody lcsh:RC581-607 business Hiv 1 gp41
Zdroj:	Retrovirology, Vol 9, Iss Suppl 2, p P348 (2012) Retrovirology
ISSN:	1742-4690
DOI:	10.1186/1742-4690-9-s2-p348
Popis:	Background The HIV-1 gp41 MPER contains the epitopes for 4 broadly neutralizing (bNt) antibodies (Abs), making it a target for vaccine design. We developed a panel of DNAvaccine candidates that link the MPER, or larger portions of gp41’s external domain, to two different transmembrane (TM) and cytoplasmic (CT) domains. We report on the ability of DNA vaccines expressing these constructs to elicit MPER-specific Nt Abs in rabbits.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2886ce865d754c82386c1554474d72 https://doi.org/10.1186/1742-4690-9-s2-p348 Zobrazit plný text záznamu Full text from SpringerLink