Comparative evaluation of the antifungal susceptibility of Candida isolates from blood specimens: results of a study in a tertiary care hospital in Bursa, Turkey

Autor: SEVİM AKÇAĞLAR, GÜHER GÖRAL, BEYZA ENER, CANAN EVCİ
Přispěvatelé: Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı., Evci, Canan, Ener, Beyza, Göral, Güher, Akçağlar, Sevim, AAG-8523-2021
Jazyk: turečtina
Rok vydání: 2014
Předmět:
Candidemia
Invasive Candidiasis
Candida Parapsilosis
Broth dilution
Candida parapsilosis
Blood sampling
Antifungal susceptibility tests
Candida glabrata
Clinical practice
Albicans
Turkey (bird)
Candida albicans
Candida krusei
Kluyveromyces marxianus
Fluconazole
Antifungal susceptibility testing
Fungicides
Candida
Fungus culture
Minimum inhibitory concentration
Candida zeylanoides
General Medicine
Medicine
general & internal
Antimicrobial surveillance program
Tertiary health care
Broth microdilution
Pichia anomala
Amphotericin-B
Article
Incubation time
Blood specimens
Amphotericin B
Key words: Candida species
antifungal susceptibility tests
Candida species
Clinical evaluation
Candida tropicalis
Antifungal agents
Susceptibility tests
Stream infections
Kefyr
National-committee
Comparative evaluations
Antifungal resistance
Nonhuman
bacterial infections and mycoses
Etest method
Clinical practices
Candida türleri
Fungus isolation
Voriconazole
Macrodilution
Comparative study
Trends
General & internal medicine
Antifungal duyarlılık testleri
Antifungal susceptibility
Zdroj: Volume: 40, Issue: 1 141-149
Turkish Journal of Medical Sciences
ISSN: 1300-0144
1303-6165
Popis: Aim: Antifungal susceptibility testing may be an important aid in the treatment of patients with life threatening yeast infections. The aim of this study was to determine the susceptibility of Candida isolates obtained from clinical specimens to the antifungal agents amphotericin B and fluconazole, which are frequently used in our clinical practice. Materials and methods: Susceptibility to antifungal agents was investigated using the Etest (AB Biodisk, Solna, Sweden) and the reference broth macrodilution susceptibility test (CLSI M27-A2). The MICs obtained with each of the methods were read after 24 h and 48 h of incubation. Results: Overall agreement rates within +/- 1 dilution between the 2 methods were 86.7% (24 h) and 94.1% (48 h) for amphotericin B, and 85.5% (24 h) and 73.3% (48 h) for fluconazole. All C. albicans, C. pelliculosa, C. glabrata, and C. kefyr isolates were inhibited by
Databáze: OpenAIRE
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