Orthogonal Synthesis of Fluorinated Acridones and Acridines from Perfluorobenzophenone
| Autor: | Silvia Rizzato, Luciano Miozzo, Ramona Gironda, Matteo Parravicini, Paola Del Buttero, Antonio Papagni, Massimo Moret |
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| Přispěvatelé: | Del Buttero, P, Gironda, R, Moret, M, Papagni, A, Parravicini, M, Rizzato, S, Miozzo, L |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Substitution reaction
Radical-nucleophilic aromatic substitution Chemistry Organic Chemistry Regioselectivity Fluorine Combinatorial chemistry Nucleophilic substitution Nitrogen heterocycle Nucleophile Nucleophilic aromatic substitution Solvent effects CHIM/06 - CHIMICA ORGANICA Organic chemistry Pericyclic reaction Acid hydrolysis Physical and Theoretical Chemistry |
| Popis: | The reaction between perfluorobenzophenone and aromatic amines proceeds with the substitution of one or more fluorine atoms. The regiochemistry of this substitution is controlled by solvent polarity, temperature, and nucleophilic character of the amine. o-Anilinononafluorobenzophenone can be selectively transformed into acridines or acridones by using acid or base catalysis through electrocyclization or aromatic nucleophilic substitution. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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