The neuropsychopharmacology of cannabis:a review of human imaging studies
| Autor: | Matthew B. Wall, Sebastian F. Green, Katherine Petrilli, M Olabisi Ogunbiyi, Michael A P Bloomfield, Tom P. Freeman, Matthijs G. Bossong, Harry Costello, Rachel Lees, Chandni Hindocha |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
CBD Cannabidiol Marijuana Abuse Cannabinoid receptor MRI Magnetic resonance imaging medicine.medical_treatment EEG Electroencephalography HIGH-POTENCY CANNABIS Review BOLD Blood-oxygen-level dependent PET Positron emission tomography 0302 clinical medicine Cognition MAGNETIC-RESONANCE Pharmacology (medical) FREQUENT MARIJUANA USE Pharmacology & Pharmacy Dronabinol Non-U.S. Gov't biology Research Support Non-U.S. Gov't Brain FUNCTIONAL CONNECTIVITY CBF Cerebral blood flow Neuropsychopharmacology STRIATAL DOPAMINE RELEASE MRS Magnetic resonance spectroscopy SPATIAL WORKING-MEMORY OFC Orbitofrontal cortex 030220 oncology & carcinogenesis PFC Prefrontal cortex CT Computed tomography DLPFC Dorsolateral prefrontal cortex ASL Arterial spin labelling 1115 Pharmacology and Pharmaceutical Sciences THC Δ9-Tetrahydrocannabinol MID Monetary incentive delay Life Sciences & Biomedicine medicine.drug FDG Fludeoxyglucose Diagnostic Imaging medicine.medical_specialty EARLY-ONSET SCHIZOPHRENIA Human Development DTI Diffusion tensor imaging Addiction Neuroimaging Development Research Support Article NAA N-Acetylaspartate 03 medical and health sciences D2R Dopamine type 2 receptor fMRI Functional magnetic resonance imaging medicine Journal Article GABA γ-Aminobutyric acid Animals Humans Psychiatry Tetrahydrocannabinol Effects of cannabis Cannabis Pharmacology Psychotropic Drugs Science & Technology PCC Posterior cingulate cortex business.industry Psychoactive drug D-2/D-3 RECEPTOR AVAILABILITY biology.organism_classification Psychosis 030104 developmental biology NAc Nucleus accumbens ANTERIOR CINGULATE CORTEX CEREBRAL-BLOOD-FLOW Cannabinoid ACC Anterior cingulate cortex business Cannabidiol CB1R Endocannabinoid type 1 receptor |
| Zdroj: | Bloomfield, M A P, Hindocha, C, Green, S F, Wall, M B, Lees, R, Petrilli, K, Costello, H, Olabisi Ogunbiyi, M, Bossong, M G & Freeman, T P 2018, ' The neuropsychopharmacology of cannabis : a review of human imaging studies ', Pharmacology and Therapeutics . https://doi.org/10.1016/j.pharmthera.2018.10.006 Pharmacology & Therapeutics Pharmacology & Therapeutics, 195, 132. Elsevier Inc. Bloomfield, M A P, Hindocha, C, Green, S F, Wall, M B, Lees, R, Petrilli, K, Costello, H, Olabisi Ogunbiyi, M, Bossong, M G & Freeman, T P 2018, ' The neuropsychopharmacology of cannabis: a review of human imaging studies ', Pharmacology and Therapeutics . https://doi.org/10.1016/j.pharmthera.2018.10.006 |
| ISSN: | 0163-7258 |
| DOI: | 10.1016/j.pharmthera.2018.10.006 |
| Popis: | The laws governing cannabis are evolving worldwide and associated with changing patterns of use. The main psychoactive drug in cannabis is Δ9-tetrahydrocannabinol (THC), a partial agonist at the endocannabinoid CB1 receptor. Acutely, cannabis and THC produce a range of effects on several neurocognitive and pharmacological systems. These include effects on executive, emotional, reward and memory processing via direct interactions with the endocannabinoid system and indirect effects on the glutamatergic, GABAergic and dopaminergic systems. Cannabidiol, a non-intoxicating cannabinoid found in some forms of cannabis, may offset some of these acute effects. Heavy repeated cannabis use, particularly during adolescence, has been associated with adverse effects on these systems, which increase the risk of mental illnesses including addiction and psychosis. Here, we provide a comprehensive state of the art review on the acute and chronic neuropsychopharmacology of cannabis by synthesizing the available neuroimaging research in humans. We describe the effects of drug exposure during development, implications for understanding psychosis and cannabis use disorder, and methodological considerations. Greater understanding of the precise mechanisms underlying the effects of cannabis may also give rise to new treatment targets. |
| Databáze: | OpenAIRE |
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