BOTULINUM TOXIN: FROM SPASTICITY RELIEVER TO A NEUROMOTOR RE-LEARNING TOOL
| Autor: | R. V. Krishnan |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Botulinum Toxins
Neurological disorder Cerebral palsy Neuroplasticity medicine Humans Spasticity Spinal cord injury Neurorehabilitation Motor Neurons Neuronal Plasticity Anti-Dyskinesia Agents business.industry musculoskeletal neural and ocular physiology General Neuroscience General Medicine medicine.disease Botulinum toxin Hebbian theory Spinal Cord Muscle Spasticity Nerve Net medicine.symptom business Neuroscience Locomotion medicine.drug |
| Zdroj: | International Journal of Neuroscience. 115:1451-1467 |
| ISSN: | 1543-5245 0020-7454 |
| DOI: | 10.1080/00207450590956576 |
| Popis: | Botulinum toxin is becoming increasingly popular as the drug of choice for relief of spasticity in a wide range of conditions, from stroke to strabismus to vaginismus. Besides this role as spasticity reliever, several recent clinical reports claim that in stroke, cerebral palsy, spinal cord injury (SCI), and dystonias, BoTx brings about significant improvement in function--attributed to synaptic plasticity of the muscular afferents. The authors' research had shown that BoTx also generates synaptic plasticity in spinal alpha-motoneurons-interneurons. The article describes how BoTx facilitates relearning by Hebbian and Contrastive Hebbian modes and how it can be used as a neuro-relearning tool to enhance and hasten motor recovery in the aforementioned disorders. |
| Databáze: | OpenAIRE |
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