Comparison Between Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers for Incidence of Lung Cancer: A Retrospective Study
| Autor: | Fnu Murlidhar, Pardeep Kumar, Sidra Memon, Aliya Fatima, Muhammad Khizar Memon, Maha Jahangir, Dua Khalid, Besham Kumar, Vinod Kumar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pulmonology Cardiology renin angiotensin alderosterone system urologic and male genital diseases Internal medicine medicine Outpatient clinic cardiovascular diseases Lung cancer Lung biology business.industry Incidence (epidemiology) Hazard ratio General Engineering association Angiotensin-converting enzyme Retrospective cohort study medicine.disease Confidence interval ace (angiotensin converting enzyme) angiotensin receptor blockers lung cancer medicine.anatomical_structure Oncology biology.protein business |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Introduction: Angiotensin-converting enzyme inhibitor (ACEI) and angiotensin II receptor blockers (ARBs) are taken as the first treatment option for hypertensive patients. The various global trials have suggested that ACEIs and ARBs may increase risk of lung cancer; however, the results are contradictory and there is no local study available. This study is conducted to compare the incidence of lung cancers in patients on ACEIs and ARBs. Methods: This retrospective study, conducted in a major cardiology unit of a tertiary care hospital in Pakistan, included patients diagnosed with hypertension, between 2005 and 2010, who were prescribed either ACEIs or ARBs. During the period of 2005 to 2010, 47,823 naïve hypertensive patients were reported in the outpatient department of the cardiology unit. Of which, 22,241 were prescribed ACEI and 25,582 were prescribed ARBs. After sorting patient data based on our inclusion criteria, n = 14,891 participants were included in the ACEI group and n = 19,112 participants were included in the ARB group. Results: The incidence of lung cancer in the ACEI and ARB group was n = 165 and n = 160, respectively. In this study, the overall incidence rates of lung cancer in the ACEI and ARB cohorts were 12.2 and 16.6 per 10,000 person-years, respectively. The hazard ratio was 1.32 (95% confidence interval: 1.06-1.64; p-value: 0.01). Conclusion: In this study, the incidence of lung cancer was relatively more among people using ACEIs than ARBs. Hence, patients undergoing long-term treatment with ACEIs need regular follow-up and proper scanning to avoid grave complications. |
| Databáze: | OpenAIRE |
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