| Autor: |
Bahador Bagheri, Sohrabi, Bahram, Movassaghpour, Ali Akbar, Mashayekhi, Simin, Afagh Garjani, Mehriar Shokri, Pezeshkian, Masoud, Alireza Garjani |
| Jazyk: |
angličtina |
| Rok vydání: |
1996 |
| Předmět: |
|
| DOI: |
10.6091/ibj.12752.2013 |
| Popis: |
Bacground: Evidence from several lines of investigations suggests that Toll-like receptor 4 (TLR4) is involved in atherosclerosis as a bridge between innate and acquired immunity. Percutaneous coronary intervention (PCI) can trigger inflammation through activation of human TLR4 (hTLR4) on monocytes. Hydrocortisone as an anti-inflammatory and immuno-suppressant agent has multiple mechanisms of action. In this study, we aimed at assessing the effects of hydrocortisone on monocyte expression and activity of hTLR4 in patients underwent PCI. Methods: Blood samples were taken from a total of 71 patients with chronic stable angina who were scheduled for a PCI, before the intervention. Thirty patients received 100 mg hydrocortisone prior to the procedure. Control group was composed of 41 patients underwent PCI without receiving hydrocortisone. Blood collection was repeated 2 and 4 h after PCI. The expression of hTLR4 on the surface of CD14+ monocytes and the serum levels of TNF-α and IL-1β were measured using flowcytometry and Sandwich ELISA. Results: Compared with controls, hydrocortisone significantly reduced monocyte expression of hTLR4 in test group (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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