Angiopep-2-modified calcium arsenite-loaded liposomes for targeted and pH-responsive delivery for anti-glioma therapy
| Autor: | Hangsheng Zheng, Hengwu Xu, Fanzhu Li, Ji-Gang Piao, Hongyue Zheng, Bin-hui Wang, Yinghui Wei, Chaoqun Li |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Arsenites Biophysics Mice Nude chemistry.chemical_element Calcium Blood–brain barrier Biochemistry Mice 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine Arsenic Trioxide Cell Line Tumor Glioma PEG ratio medicine Animals Humans Tissue Distribution Arsenic trioxide Receptor Molecular Biology Tumor microenvironment Liposome Cell Cycle Cell Biology Hydrogen-Ion Concentration medicine.disease Xenograft Model Antitumor Assays 030104 developmental biology medicine.anatomical_structure chemistry Blood-Brain Barrier 030220 oncology & carcinogenesis Liposomes Cancer research Peptides |
| Zdroj: | Biochemical and Biophysical Research Communications. 551:14-20 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2021.02.138 |
| Popis: | The blood-brain barrier (BBB) is the most critical obstacle in the treatment of central nervous system disorders, such as glioma, the most typical type of brain tumor. To overcome the BBB and enhance drug-penetration abilities, we used angiopep-2-modified liposomes to deliver arsenic trioxide (ATO) across the BBB, targeting the glioma. Angiopep-2-modified calcium arsenite-loaded liposomes (A2–PEG–LP@CaAs), with uniformly distributed hydrodynamic diameter (96.75 ± 0.57 nm), were prepared using the acetate gradient method with high drug-loading capacity (7.13 ± 0.72%) and entrapment efficiency (54.30 ± 9.81%). In the acid tumor microenvironment, arsenic was responsively released, thereby exerting an anti-glioma effect. The anti-glioma effect of A2–PEG–LP@CaAs was investigated both in vitro and in vivo. As a result, A2–PEG–LP@CaAs exhibited a potent, targeted anti-glioma effect mediated by the lipoprotein receptor-related (LRP) receptor, which is overexpressed in both the BBB and glioma. Therefore, A2–PEG–LP@CaAs could dramatically promote the anti-glioma effect of ATO, as a promising strategy for glioma therapy. |
| Databáze: | OpenAIRE |
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