Sleep apnea in Machado-Joseph disease: a clinical and polysomnographic evaluation
| Autor: | Orlando Graziani Povoas Barsottini, Lucila Bizari Fernandes do Prado, Felipe Augusto Folha Santos, Luciane Bizari Coin de Carvalho, José Luiz Pedroso, Gilmar Fernandes do Prado |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities Pediatrics medicine.medical_specialty Ataxia Polysomnography Disorders of Excessive Somnolence 03 medical and health sciences 0302 clinical medicine Excessive daytime somnolence medicine Humans 030212 general & internal medicine Sleep disorder Sleep Apnea Obstructive medicine.diagnostic_test business.industry Sleep apnea General Medicine Machado-Joseph Disease medicine.disease Obstructive sleep apnea Spinocerebellar ataxia Quality of Life Female medicine.symptom business Machado–Joseph disease 030217 neurology & neurosurgery Brazil |
| Zdroj: | Sleep medicine. 48 |
| ISSN: | 1878-5506 |
| Popis: | Objective/Background Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is the most common type of autosomal dominant spinocerebellar ataxia (SCA). Sleep disorders have been described as frequent non-motor symptoms in MJD, and with marked impairment on quality of life. However, few studies have evaluated the frequency and characteristics of sleep apnea in MJD. Patients/Methods This study analyzed the prevalence of sleep apnea in 47 patients with MJD by using polysomnography. Clinical variables such as age, age at onset of symptoms, duration of symptoms (at time of evaluation), body index mass, ataxia scales severity and CAG repeat length were compared with polysomnographic findings. Results Thirty four percent of MJD patients had OSAS, and 42.5% had excessive daytime somnolence. There were no differences considering ataxia severity, CAG repetition length or other clinical variable. Conclusions Patients with MJD have high frequency of obstructive sleep apnea, and this sleep disorder is not correlated with ataxia severity, CAG repetition length or other clinical variable. |
| Databáze: | OpenAIRE |
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