Impaired clearance and organ localization of Candida albicans in obstructive jaundice
| Autor: | Jay L. Grosfeld, Raoul S. Rosenthal, Glenn J. Merkel, Walter J. Folkening, Schmuel Katz |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Pathology Kidney Gastroenterology Sepsis Distal Common Bile Duct Internal medicine Candida albicans medicine Animals Distribution (pharmacology) Ligation Lung Cholestasis biology business.industry Candidiasis Rats Inbred Strains General Medicine biology.organism_classification medicine.disease Rats medicine.anatomical_structure Liver Pediatrics Perinatology and Child Health Surgery Obstructive jaundice Disease Susceptibility business Fungemia Spleen Bacteria |
| Zdroj: | Journal of Pediatric Surgery. 26:904-907 |
| ISSN: | 0022-3468 |
| DOI: | 10.1016/0022-3468(91)90834-g |
| Popis: | Sepsis is a major cause of morbidity and mortality in infants with cholestatic jaundice. This may be attributed to altered host defense mechanisms. Fungal infection frequently occurs in immunocompromised patients. This study evaluates the effect of biliary obstruction on blood clearance and organ localization of radiolabeled viable Candida albicans . Male Sprague-Dawley rats (140 to 150 g) were placed in 2 groups. Group I (n = 30) were sham-operated controls. Group II (n = 90) underwent ligation and division of the distal common bile duct (CDL). At 1,2, and 3 weeks following CDL, 10 7 cells/mL radiolabeled viable C albicans were injected via the tail vein. The final distribution of the organisms was calculated and expressed as the mean percent of radiolabeled organisms per gram and per total organ. Blood clearance of C albicans was similarly rapid in both groups. However, there was a significant decrease in the trapping of fungi by the rat liver Kupffer cells (20.3% ± 7.9% v control 42.5% ± 15%; P > .001), and increased pulmonary localization of bacteria 3 weeks following CDL (53.6% ± 13.2% v control 41.4% ± 6.4%). The significant decrease in liver trapping and increased lung localization of C albicans in CDL rats, may result in systemic reemergence of fungi and play a role in the susceptibility to fungal infection in jaundiced subjects. |
| Databáze: | OpenAIRE |
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