Treatment of Paget's Disease of Bone with Mithramycin
| Autor: | John R. Condon, J. R. Nassim, E. M. Stainthorpe, F. J. C. Millard, A. Hilb, S. B. M. Reith |
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| Rok vydání: | 1971 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Anabolism Parathyroid hormone chemistry.chemical_element macromolecular substances Calcium Bone resorption Hydroxyproline chemistry.chemical_compound Internal medicine otorhinolaryngologic diseases medicine Bone pain General Environmental Science Antibiotics Antineoplastic business.industry musculoskeletal neural and ocular physiology General Engineering Papers and Originals General Medicine Alkaline Phosphatase medicine.disease Endocrinology Paget's disease of bone nervous system chemistry General Earth and Planetary Sciences Alkaline phosphatase medicine.symptom business |
| Zdroj: | BMJ. 1:421-423 |
| ISSN: | 1468-5833 0959-8138 |
| Popis: | We report data from three patients with severe Paget's disease of bone who were treated with mithramycin.Mithramycin infusion resulted in a fall in plasma calcium, phosphate, alkaline phosphatase, and urinary hydroxyproline excretion. There was an improvement in calcium and phosphorus balance in two of the three subjects studied. A pronounced or complete relief of bone pain occurred in all three.We suggest that mithramycin exerts its beneficial effect in Paget's disease of bone by stimulating parathyroid hormone release. The parathyroid hormone released has a predominantly anabolic action on bone since its catabolic action is blocked by mithramycin, which inhibits bone resorption. |
| Databáze: | OpenAIRE |
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