Imepitoin withdrawal in dogs with idiopathic epilepsy well-controlled with imepitoin and phenobarbital and/or potassium bromide does not increase seizure frequency
| Autor: | Kimberley Stee, Sofie Bhatti, L. Van Ham, Valentine Martlé, Bart J. G. Broeckx, E. Royaux |
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| Rok vydání: | 2017 |
| Předmět: |
Bromides
Male 0301 basic medicine Potassium Compounds 040301 veterinary sciences 0403 veterinary science 03 medical and health sciences Epilepsy Dogs Seizures medicine Animals Dog Diseases Adverse effect Seizure frequency General Veterinary business.industry Imidazoles 04 agricultural and veterinary sciences medicine.disease Treatment Outcome 030104 developmental biology Tolerability Phenobarbital Anesthesia Maximum dose Anticonvulsants Drug Therapy Combination Female Animal Science and Zoology Epileptic seizure medicine.symptom Once daily business medicine.drug |
| Zdroj: | The Veterinary Journal. 230:1-5 |
| ISSN: | 1090-0233 |
| DOI: | 10.1016/j.tvjl.2017.10.003 |
| Popis: | Phenobarbital or potassium bromide (KBr) add-on treatment decreases the average monthly seizure frequency in dogs with idiopathic epilepsy resistant to a maximum dose of imepitoin. The importance of continued administration of imepitoin in these dogs is currently unknown. The goal of this study was to assess whether imepitoin withdrawal would destabilize epileptic seizure control. In this prospective clinical trial epileptic seizure control was evaluated by comparing the monthly seizure frequency of 13 dogs with well-controlled idiopathic epilepsy receiving a combination of imepitoin and phenobarbital (n=4), imepitoin and KBr (n=7), and imepitoin, phenobarbital and KBr (n=2) during a period of 3-6 months (pre-withdrawal period), with a follow-up period of 9-12 months after withdrawal of imepitoin (post-withdrawal period). Adverse effects were also recorded before and after withdrawal of imepitoin. Imepitoin was tapered off over 3 months as follows: 20mg/kg twice daily for 1 month, then 10mg/kg twice daily for 1 month, then once daily for 1 month. Withdrawal of imepitoin did not increase monthly seizure frequency (P=0.9). Moreover, all owners reported improvement in the adverse effects experienced by their dog after withdrawal of imepitoin. Imepitoin withdrawal in epileptic dogs that were well-controlled with imepitoin and phenobarbital and/or KBr did not worsen epileptic seizure control, and possibly decreased antiepileptic treatment-related adverse effects. However, a worsening of seizure frequency could occur in individual cases. |
| Databáze: | OpenAIRE |
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