Is Dopamine a Physiological Natriuretic Hormone in the Dog?
| Autor: | G. Jondeau, F Selz, J. L. Cuche, G Ruget, J. Guedon |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
medicine.medical_specialty Fractional excretion of sodium Dopamine Sodium Natriuresis chemistry.chemical_element Sodium Chloride Norepinephrine Dogs Body Water Internal medicine Extracellular fluid medicine Extracellular Animals Kidney General Medicine medicine.anatomical_structure Endocrinology chemistry Catecholamine Tonicity Female Extracellular Space medicine.drug |
| Zdroj: | Clinical Science. 65:479-486 |
| ISSN: | 1470-8736 0143-5221 |
| DOI: | 10.1042/cs0650479 |
| Popis: | 1. Both plasma and urinary dopamine and noradrenaline were measured as free and sulphate conjugates, by a radioenzymatic method, before and during extracellular volume expansion (ECVE) with hypo-, iso- or hyper-tonic fluid (usually sodium chloride solution) in dogs. 2. During ECVE there was a decrease in plasma catecholamine concentration. For all cases except noradrenaline, this is probably due to a dilution phenomenon since when results were expressed as pg/mg of protein, ECVE had no effect. This change in noradrenaline accounted for the increase in the dopamine/noradrenaline ratio. 3. As expected, there was an increase in the urinary excretion of dopamine during ECVE with both iso- and hyper-tonic fluid. This increase was not observed in the group of dogs given hypotonic fluid, although the increase of fractional excretion of sodium was of a similar order of magnitude. 4. The increase in the urinary excretion of dopamine was apparently not affected by an increase in plasma sodium concentration and/or osmolality. 5. The demonstrated dissociation between sodium and dopamine in urine does not support a physiological role for dopamine in renal handling of sodium during ECVE, and raises the question of its specificity. |
| Databáze: | OpenAIRE |
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