Water exposure assessment of aryl hydrocarbon receptor agonists in Three Gorges Reservoir, China using SPMD-based virtual organisms
| Autor: | Silke Bernhöft, Jingxian Wang, Karl-Werner Schramm, Gerd Pfister |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Agonist
China Environmental Engineering Polychlorinated Dibenzodioxins medicine.drug_class medicine Cytochrome P-450 CYP1A1 Water Pollution Chemical Environmental Chemistry Bioassay Animals Computer Simulation Waste Management and Disposal Three gorges Exposure assessment Pollutant biology Chemistry Aryl hydrocarbon receptor Pollution Receptors Aryl Hydrocarbon Environmental chemistry biology.protein Composition (visual arts) Biological Assay Antagonism Water Pollutants Chemical |
| Zdroj: | The Science of the total environment. 496 |
| ISSN: | 1879-1026 |
| Popis: | SPMD-based virtual organisms (VOs) were deployed at five to eight sites in the Three Gorges Reservoir (TGR), China for five periods in 2008, 2009 and 2011. The water exposure of aryl hydrocarbon receptor (AhR) agonists was assessed by the VOs. The chosen bioassay response for the extracts of the VOs, the induction of 7-ethoxyresorufin-O-deethylase (EROD) was assayed using a rat hepatoma cell line (H4IIE). The results show that the extracts from the VOs could induce AhR activity significantly, whereas the chemically derived 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) equivalent (TEQ(cal)) accounted for |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect