Relationship between subendocardial viability ratio and hemoglobin in patients with chronic kidney disease
| Autor: | Eva Jakopin, Tina Stropnik Galuf, Igor Krajnc, Sebastjan Bevc, Robert Ekart, Radovan Hojs, Maša Knehtl, Nina Hojs, Martin Hren, Benjamin Dvoršak |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Ambulatory blood pressure Anemia 030232 urology & nephrology Diastole 030204 cardiovascular system & hematology Pulse Wave Analysis 03 medical and health sciences Hemoglobins 0302 clinical medicine Internal medicine Troponin I Natriuretic Peptide Brain medicine Humans Renal Insufficiency Chronic Aged Aged 80 and over biology business.industry General Medicine Blood Pressure Monitoring Ambulatory Middle Aged medicine.disease Peptide Fragments Pulse pressure Cystatin C Nephrology Cardiology biology.protein Female Hemoglobin business Kidney disease Endocardium |
| Zdroj: | Clinical nephrology. 88(13) |
| ISSN: | 0301-0430 |
| Popis: | Aims Pulse wave analysis (PWA) uses the technique of applanation tonometry to obtain a peripheral pulse pressure waveform from which central hemodynamic information is derived. Using PWA, subendocardial viability ratio (SEVR) can be measured. SEVR represents a noninvasive measure of myocardial perfusion. It is related to the work of the heart, the oxygen consumption, and the energy supply of the heart. Anemia is a common complication of chronic kidney disease (CKD). A complex relationship exists between CKD, cardiovascular disease (CVD), and anemia. The aim of our study was to assess the relationship between SEVR and hemoglobin in non-dialysis CKD patients. Material and methods We examined the associations between PWA hemodynamic parameters, 24-hour ambulatory blood pressure (BP) measurements, and laboratory variables including hemoglobin, cardiac biomarkers troponin I, NT-proBNP, and hs-CRP in a cohort of 91 nondialysis CKD patients. PWA was assessed by radial applanation tonometry (SphygmoCor, Atcor, Sydney, Australia). The patients were divided into two groups according to the median value of hemoglobin. Results Mean age of included patients was 60.2 years, 67% were men, 44% were smokers, 25.3% had diabetes. A significant correlation between hemoglobin and SEVR was found (r = 0.26; p = 0.012). With multivariate regression analysis, SEVR as dependent variable turned out to be statistically significantly associated with hemoglobin (β = 0.344, p = 0.013) and with troponin I (β = -0.217, p = 0.037). Patients in the group with lower hemoglobin had statistically-significantly higher serum creatinine, cystatin C, NT-proBNP, and 24-hour ambulatory systolic BP and lower e-GFR, SEVR, and office diastolic BP. Conclusions Results of our study show that SEVR is independently associated with hemoglobin in nondialysis CKD patients. CKD patients with lower hemoglobin have lower SEVR. . |
| Databáze: | OpenAIRE |
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