Joining Forces: Fermentation and Organic Synthesis for the Production of Complex Heterocycles
| Autor: | Claire M. Gober, Madeleine M. Joullié |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Biological Products Organic chemicals Organic Chemistry Economic feasibility Total synthesis Article 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry Heterocyclic Compounds Fermentation Production (economics) Organic synthesis Biochemical engineering Organic Chemicals |
| Zdroj: | The Journal of Organic Chemistry. 81:10136-10144 |
| ISSN: | 1520-6904 0022-3263 |
| DOI: | 10.1021/acs.joc.6b01308 |
| Popis: | Commercial application of many promising heterocyclic natural products is limited by their natural abundance. While organic synthesis provides access to many natural products, total synthesis of numerous complex molecules is not economically feasible. In recent years, the combination of fermentation and organic synthesis has provided a new route for the production of complex heterocycles that are inaccessible by typical synthetic methods. This JOCSynopsis will review examples of how this union of disciplines has overcome obstacles in both academia and industry. |
| Databáze: | OpenAIRE |
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