Enrichment of Cells with Cancer Stem Cell-Like Markers in Relapses of Chemoresistant Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma
| Autor: | Ricard Mesia, Miren Taberna, Carlos Cordon-Cardo, Ana-Belen Larque, Miguel Caballero, Estrelania Williams, Jorge de la Oliva, Juan J. Grau, Josep Domingo-Domenech, Maria de la Iglesia-Vicente |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Oncology Adult Male Cancer Research medicine.medical_specialty medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Cancer stem cell Internal medicine medicine Carcinoma Biomarkers Tumor Humans Aged biology business.industry CD44 Head and neck cancer Histocompatibility Antigens Class I General Medicine Middle Aged medicine.disease Head and neck squamous-cell carcinoma Primary tumor Radiation therapy ErbB Receptors 030104 developmental biology Hyaluronan Receptors Tumor progression Head and Neck Neoplasms 030220 oncology & carcinogenesis biology.protein Carcinoma Squamous Cell Disease Progression Neoplastic Stem Cells Keratins Female Neoplasm Recurrence Local business |
| Zdroj: | Oncology. 90(5) |
| ISSN: | 1423-0232 |
| Popis: | Background: Patients with head and neck squamous cell carcinoma (HNSCC) present different responses to chemotherapy and radiotherapy. One explanation may be the differences in the individual rates of stem cell-like cells. Methods: We included patients with HNSCC and tumor progression or relapse. Tumor samples were obtained before and after primary chemotherapy, and immunohistochemical analyses were performed for CD44, HLA class I (HLA-I), pancytokeratin, and phosphorylated epidermal growth factor receptor (p-EGFR). Differences in expression between the first and second specimens were assessed. Results: Expression between the first and second specimens varied as follows: CD44 increased by 14.67% (95% confidence interval, CI: 6.94 to 22.40; p < 0.01); HLA-I decreased by 16.72% (95% CI: -23.87 to -9.47; p < 0.01); pancytokeratin decreased by 24.91% (95% CI: -32.8 to -17.7; p < 0.01), and p-EFGR expression decreased by 12.30% (95% CI: -20.61 to -3.98; p < 0.005). Conclusions: Among patients with HNSCC, there is an enrichment of cells with stem-like markers in relapsed tumors when compared with the primary tumor. This finding should be considered when developing treatment strategies. |
| Databáze: | OpenAIRE |
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