The influence of dopamine agonists and antagonists on indomethacin lesions in stomach and small intestine in rats
| Autor: | Predrag Sikiric, Marijan Petek, Ivan Balen, Šimun Križanac, Tomislav Anic, Marko Duvnjak, Livije Kalogjera, Jerka Dr Jukic, Miroslav Philipp, Juraj Geber, Milica Tućan-Foretić, Ivan Udovicic, Veljko Gjuriš, Stjepan Mise, Ivo Rotkvić, Ernest Suchanek |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty Dopamine Agents Indomethacin Dopamine agonist Intestinal mucosa Dopamine Internal medicine Intestine Small medicine Gastric mucosa Animals Drug Interactions Stomach Ulcer Intestinal Mucosa Ulcer Pharmacology business.industry Stomach Dopamine antagonist Rats Inbred Strains Anti-Ulcer Agents Bromocriptine Domperidone Rats medicine.anatomical_structure Endocrinology Gastric Mucosa Dopamine Antagonists Female business medicine.drug |
| Zdroj: | European journal of pharmacology. 158(1-2) |
| ISSN: | 0014-2999 |
| Popis: | Dopamine agents (saline in control groups) were coadministered with indomethacin by either single or repeated application. The ulcerogenic effect (erosions and/or ulcers) of repeated given indomethacin on gastric mucosa differed clearly from that on intestinal mucosa. The effect on intestinal mucosa was markedly greater than after a single dose. The effects of dopamine agents appeared to be more consistent. Domperidone and haloperidol, given as single or repeated doses, strongly aggravated both the gastric and intestinal lesions. Bromocriptine and amantadine had a protective effect. The adverse effects of both dopamine antagonists (increased after repeated administration) were strongly inhibited by the simultaneous administration of either bromocriptine or amantadine. The involvement of the dopamine system (central or peripheral) in the mechanisms that maintain gastric (probably related to cytoprotection also) and intestinal mucosa integrity is therefore suggested. |
| Databáze: | OpenAIRE |
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