Serum vitamin A and beta-carotene concentrations and renal scarring in urinary tract infections
| Autor: | Salih Kavukçu, Erkan Derebek, Mehmet Türkmen, Benal Büyükgebiz, Nilgün Sevinç, Alper Soylu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
Vitamin
medicine.medical_specialty Urinary system Scars Gastroenterology chemistry.chemical_compound Cicatrix beta-Carotene Recurrence Internal medicine medicine Humans Child Radionuclide Imaging Vitamin A Kidney business.industry Retinol Original Articles medicine.disease beta Carotene Endocrinology medicine.anatomical_structure chemistry Dimercaptosuccinic acid Child Preschool Pediatrics Perinatology and Child Health Technetium Tc 99m Dimercaptosuccinic Acid Urinary Tract Infections Kidney Diseases medicine.symptom business Kidney disease medicine.drug |
| Popis: | OBJECTIVE—To evaluate the role of vitamin A on renal scarring in recurrent urinary tract infections (UTIs). DESIGN—Twenty three children with UTIs and renal scarring (mean (SD) age 7.3 (3.9) years) and 91 children without renal scarring (6.4 (3.4) years) were studied. All the children had serum vitamin A and β-carotene measurements and nutritional evaluation. Renal scarring was assessed by technetium-99m dimercaptosuccinic acid (99mTc DMSA) scanning. Nutritional status of all the patients was within normal limits and not different between the groups. RESULTS—Mean (SD) serum vitamin A and β-carotene concentrations were not significantly different between the patients with and without renal scarring (vitamin A 53.2 (22.6)/46.8 (17.0) µg/dl and β-carotene 232.3 (201.3)/272.4 (86.0) µg/dl respectively). However, when the patients with renal scarring and with greater than 10% difference among the DMSA uptakes of their kidneys (11 cases) were evaluated, a significant negative correlation was determined between the serum vitamin A concentrations and the magnitude of the difference in uptakes of each kidney. The same relation was not true for serum β-carotene concentrations. CONCLUSION—This study demonstrated a relation between serum vitamin A concentrations and magnitude of hypoactivity in 99mTc DMSA scanning in kidneys with advanced scarring. |
| Databáze: | OpenAIRE |
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