Thalamo-striatal T2-weighted hyperintensities (unidentified bright objects) correlate with cognitive impairments in neurofibromatosis type 1 during childhood
| Autor: | M.-A. Barthez, Bruno Giraudeau, Dominique Sirinelli, Catherine Sembely, Geraldine Deseille-Turlotte, Jean-Philippe Cottier, C. Barbier, Gérard Lorette, Pierre Castelnau, Camille Chabernaud |
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| Rok vydání: | 2010 |
| Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities Visual perception Neurofibromatosis 1 Adolescent Thalamus Basal ganglia Developmental and Educational Psychology medicine Humans Neurofibromatosis Child medicine.diagnostic_test Cognitive disorder Magnetic resonance imaging Cognition medicine.disease Magnetic Resonance Imaging Hyperintensity Corpus Striatum Neuropsychology and Physiological Psychology Space Perception Visual Perception Female T2 weighted Psychology Cognition Disorders Neuroscience |
| Zdroj: | Developmental neuropsychology. 34(6) |
| ISSN: | 1532-6942 |
| Popis: | Learning disabilities represent the main childhood complication in neurofibromatosis type 1 (NF1). Patients frequently exhibit T2-weighted hyperintensities called unidentified bright objects (UBOs) on brain magnetic resonance imaging (MRI), with unclear relationship to such cognitive disabilities. This study aimed to determine whether thalamo-striatal UBOs correlate with cognitive disturbances. Thirty-seven NF1 children were studied: 24 with UBOs (18 of which were thalamo-striatal UBOs), and 13 without UBOs. NF1 subjects carrying thalamo-striatal UBOs had significantly lower IQs and visuospatial performances than those without UBOs in this location. These results suggest that UBOs may contribute to NF1 cognitive impairments through thalamo-cortical dysfunction. |
| Databáze: | OpenAIRE |
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