Histologic study of effects of radiation synovectomy with Rhenium-188 microsphere
| Autor: | Furn F. Knapp, William-L Ho, Min-Nan Chen, Shyh-Jen Wang, Lie-Hang Shen, Bor-Tsung Hsieh, Gann Ting, Jung-Ta Chen, Wan-Yu Lin, Hen-Ton Huang |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Cartilage
Articular Male musculoskeletal diseases Cancer Research Pathology medicine.medical_specialty Knee Joint medicine.medical_treatment Articular cartilage Synovectomy Inflammation Microsphere Arthritis Rheumatoid Synovial Fluid medicine Animals Radiology Nuclear Medicine and imaging Radioisotopes Lagomorpha biology business.industry musculoskeletal system biology.organism_classification medicine.disease Microspheres Rhenium medicine.anatomical_structure Antirheumatic Agents Rheumatoid arthritis Molecular Medicine Rabbits Synovial membrane medicine.symptom business |
| Zdroj: | Nuclear Medicine and Biology. 28:727-732 |
| ISSN: | 0969-8051 |
| DOI: | 10.1016/s0969-8051(01)00228-1 |
| Popis: | Rhenium-188 microsphere is a relatively new radiation synovectomy agent developed for the treatment of rheumatoid arthritis. It has been shown that the levels of unwanted extra-articular radiation are negligible with this agent. A histologic study was conducted to assess the effect of radiation synovectomy on synovium and articular cartilage after intra-articular injection of various doses of Re-188 microspheres into the knee joints of rabbits. Intra-articular injection of Re-188 microspheres into rabbit knee joints resulted in mild reactive inflammation and thrombotic occlusion of vessels which subsided rapidly. Sclerosis of subsynovium could be seen 12 weeks after injection. No evidence of damage to articular cartilage was noted. There was no significant difference in the articular pattern after injection of 0.3 or 0.6 mCi Re-188 microspheres. This study suggests that a treatment dose of Re-188 microspheres causes transient inflammation of synovium without any detectable damage to the articular cartilage of knee joint. |
| Databáze: | OpenAIRE |
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