Geographic disparity in kidney transplantation under KAS
| Autor: | Sommer E. Gentry, Jessica M. Ruck, Dorry L. Segev, Allan B. Massie, Mary G. Bowring, Xun Luo, Sheng Zhou, Eric K.H. Chow, Sunjae Bae |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Organ procurement organization Tissue and Organ Procurement medicine.medical_treatment 030232 urology & nephrology 030230 surgery Rate ratio Article 03 medical and health sciences symbols.namesake 0302 clinical medicine Renal Dialysis medicine Humans Immunology and Allergy Pharmacology (medical) Poisson Distribution Poisson regression Kidney transplantation Dialysis Deceased donor kidney Transplantation Health Care Rationing Geography business.industry Middle Aged medicine.disease Kidney Transplantation Kidney allocation symbols Female business Demography |
| Zdroj: | American Journal of Transplantation. 18:1415-1423 |
| ISSN: | 1600-6135 |
| Popis: | The Kidney Allocation System fundamentally altered kidney allocation, causing a substantial increase in regional and national sharing that we hypothesized might impact geographic disparities. We measured geographic disparity in deceased donor kidney transplant (DDKT) rate under KAS (6/1/2015-12/1/2016), and compared that with pre-KAS (6/1/2013-12/3/2014). We modeled DSA-level DDKT rates with multilevel Poisson regression, adjusting for allocation factors under KAS. Using the model we calculated a novel, improved metric of geographic disparity: the median incidence rate ratio (MIRR) of transplant rate, a measure of DSA-level variation that accounts for patient casemix and is robust to outlier values. Under KAS, MIRR was 1.75 1.811.86 for adults, meaning that similar candidates across different DSAs have a median 1.81-fold difference in DDKT rate. The impact of geography was greater than the impact of factors emphasized by KAS: having an EPTS score ≤20% was associated with a 1.40-fold increase (IRR = 1.35 1.401.45 , P < .01) and a three-year dialysis vintage was associated with a 1.57-fold increase (IRR = 1.56 1.571.59 , P < .001) in transplant rate. For pediatric candidates, MIRR was even more pronounced, at 1.66 1.922.27 . There was no change in geographic disparities with KAS (P = .3). Despite extensive changes to kidney allocation under KAS, geography remains a primary determinant of access to DDKT. |
| Databáze: | OpenAIRE |
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