Long-acting contraceptive agents: Esters of norethisterone with α- and/or β-chain branching
| Autor: | J. Muller, M. Hosking, S. Cruz, M. Vossoghi, Subramaniam Sotheeswaran, V. Puvanesarajah, A. Murillo, Abbas Shafiee, J.V. Torres, Thomas G. Watson, F. Savabi, Josef E. Herz |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Magnetic Resonance Spectroscopy
Norethisterone medicine.medical_treatment Clinical Biochemistry Ether Pharmacology Branching (polymer chemistry) Biochemistry Chemical synthesis Medicinal chemistry Steroid Structure-Activity Relationship chemistry.chemical_compound Endocrinology medicine Molecular Biology Control effect business.industry Organic Chemistry Esters Long acting chemistry Spectrophotometry Indicators and Reagents Norethindrone business Enone medicine.drug |
| Zdroj: | Steroids. 41:255-265 |
| ISSN: | 0039-128X |
| DOI: | 10.1016/0039-128x(83)90096-x |
| Popis: | The synthesis of eighteen esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) is described. These all possess some form of alpha- and/or beta-substitution in the ester side-chain. The work was undertaken in order to evaluate any long-acting fertility control effect intrinsic in such compounds. A pentamethyl disiloxy ether was also included in the group of substances prepared for testing because of its similar substitution pattern. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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