Atypical antipsychotic poisoning in young children: a multicentre analysis of poisons centres data
| Autor: | Alessandro Ceschi, Dagmar Prasa, Petra Hoffmann-Walbeck, Elke Färber, Uwe Stedtler, Gerd A. Kullak-Ublick, Christine Rauber-Lüthy, Marianne Meli, Hans-Jürgen Reinecke, Hugo Kupferschmidt, Dieter Genser |
|---|---|
| Přispěvatelé: | University of Zurich, Ceschi, Alessandro |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Olanzapine
Male medicine.medical_specialty Pediatrics Poison Control Centers medicine.drug_class medicine.medical_treatment Atypical antipsychotic Poison control 610 Medicine & health Germany medicine Humans 2735 Pediatrics Perinatology and Child Health Psychiatry Antipsychotic Clozapine Retrospective Studies Risperidone business.industry Glasgow Coma Scale Infant 10199 Clinic for Clinical Pharmacology and Toxicology Austria Child Preschool Pediatrics Perinatology and Child Health Quetiapine Female business Switzerland medicine.drug Antipsychotic Agents |
| Popis: | Although paediatric patients frequently suffer from intoxications with atypical antipsychotics, the number of studies in young children, which have assessed the effects of acute exposure to this class of drugs, is very limited. The aim of this study was to achieve a better characterization of the acute toxicity profile in young children of the atypical antipsychotics clozapine, olanzapine, quetiapine, and risperidone. We performed a multicentre retrospective analysis of cases with atypical antipsychotics intoxication in children younger than 6 years, reported by physicians to German, Austrian, and Swiss Poisons Centres for the 9-year period between January 1, 2001 and December 31, 2009. One hundred and six cases (31 clozapine, 29 olanzapine, 12 quetiapine, and 34 risperidone) were available for analysis. Forty-seven of the children showed minor, 28 moderate, and 2 severe symptoms. Twenty-nine cases were asymptomatic. No fatalities were recorded. Symptoms predominantly involved the central nervous and cardiovascular systems. Minor reduction in vigilance (Glasgow Coma Scale score >9) (62 %) was the most frequently reported symptom, followed by miosis (12 %) and mild tachycardia (10 %). Extrapyramidal motor symptoms were observed in one case (1 %) after ingestion of risperidone. In most cases, surveillance and supportive care were sufficient to achieve a good outcome, and all children made full recovery. Conclusions: Paediatric antipsychotic exposure can result in significant poisoning; however, in most cases only minor or moderate symptoms occurred and were followed by complete recovery. Symptomatic patients should be monitored for central nervous system depression and an electrocardiogram should be obtained. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|