Growth-Factor Nanocapsules That Enable Tunable Controlled Release for Bone Regeneration
| Autor: | Yunfeng Lu, Haijun Tian, Trevor P. Scott, Tetsuo Hayashi, Alobaidaan Raed, Michael D. Daubs, Akinobu Suzuki, Jeffrey C. Wang, Yang Liu, Gil S. Weintraub, Xu Bo Yuan, Monchai Ruangchainikom, Xianjin Yang, Jing Wen, Kevin Phan, Samuel S. Murray, Bayan Aghdasi, Scott R. Montgomery, Chengjie Xiong, Juanjuan Du |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Materials science Bone Regeneration Polymer composition Polymers Growth factor medicine.medical_treatment General Engineering General Physics and Astronomy Nanotechnology 02 engineering and technology 021001 nanoscience & nanotechnology Controlled release Regenerative medicine Nanocapsules 03 medical and health sciences 030104 developmental biology In vivo Delayed-Action Preparations medicine General Materials Science In situ polymerization 0210 nano-technology Bone regeneration |
| Zdroj: | ACS nano. 10(8) |
| ISSN: | 1936-086X |
| Popis: | Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited by the short in vivo half-lives and the narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. In this research, a nanoscale controlled release system (degradable protein nanocapsule) is established via in situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes can be achieved with growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 nanocapsules. |
| Databáze: | OpenAIRE |
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