Discovery of (R)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: a novel NR1/2B subtype selective NMDA receptor antagonist
| Autor: | Ramanjit Gill, Emmanuel Pinard, Marie-Paule Heitz, Vincent Mutel, Alexander Alanine, Rene Wyler, Anne Bourson, Georg Jaeschke, Gerhard Trube, Bernd Büttelmann |
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| Rok vydání: | 2001 |
| Předmět: |
Adrenergic receptor
Stereochemistry Organic Chemistry Clinical Biochemistry Glutamate receptor Antagonist Pharmaceutical Science Biochemistry Chemical synthesis Receptors N-Methyl-D-Aspartate chemistry.chemical_compound nervous system chemistry Phenols Piperidines Receptors Adrenergic alpha-1 Drug Discovery Molecular Medicine NMDA receptor Stereoselectivity Enantiomer Molecular Biology Lead compound Excitatory Amino Acid Antagonists |
| Zdroj: | Bioorganicmedicinal chemistry letters. 11(16) |
| ISSN: | 0960-894X |
| Popis: | Starting from Ro-25-6981 as a lead compound, highly potent and selective NR1/2B subtype selective NMDA receptor antagonists, with low activity at α 1 adrenergic receptors were developed. |
| Databáze: | OpenAIRE |
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