Volatile organic metabolites identify patients with gastric carcinoma, gastric ulcer, or gastritis and control patients
| Autor: | Yue Li, Lei Guo, Desheng Liu, Shujuan Liu, Chunjie Chi, Hongshuang Tong, Enyou Li, Yue Wang, Changsong Wang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Atrophic gastritis Gastroenterology lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Internal medicine Biopsy Genetics Carcinoma Medicine Stage (cooking) lcsh:QH573-671 Lung cancer medicine.diagnostic_test business.industry lcsh:Cytology Gastric ulcer Gastric carcinoma Cancer VOCs Gold standard (test) medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 030104 developmental biology Oncology 030220 oncology & carcinogenesis Gastritis medicine.symptom business Primary Research |
| Zdroj: | Cancer Cell International Cancer Cell International, Vol 17, Iss 1, Pp 1-9 (2017) |
| ISSN: | 1475-2867 |
| Popis: | Background Gastric cancer ranks 4th among the most common cancers worldwide, and the mortality caused by gastric cancer is 2nd only to lung cancer. Gastric cancer shows a lack of specific symptoms in its early stages. In addition, its clinical symptoms often do not match the corresponding stage. Upper gastrointestinal endoscopy with biopsy is the gold standard for the diagnosis of gastric cancer because of its high accuracy. However, this operation is invasive, patient compliance is poor, and high demands for medical staff and equipment are typical of this procedure. Recent studies have demonstrated a connection between specific breath volatile organic compounds (VOCs) and various forms of cancers. Methods We collected expired air from patients with gastric cancer, chronic atrophic gastritis or gastric ulcers as well as from healthy individuals. Solid-phase microextraction, gas chromatography–mass spectrometry and principal component analysis statistics were applied to identify potential biomarkers of gastric cancer among VOCs. Results Fourteen differential metabolites were annotated using the NIST 11 database, with a similarity threshold of 70%. Currently, the metabolic origin of VOCs remains unclear; however, several pathways might explain the decreasing or increasing trends that were observed. Conclusions The results of this study demonstrate the existence of specific VOC profiles associated with patients with carcinoma. In addition, these metabolites may contribute to the diagnosis and screening of patients with carcinoma. |
| Databáze: | OpenAIRE |
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