Enhanced oral delivery and anti-gastroesophageal reflux activity of curcumin by binary mixed micelles

Autor:	Yongshun Sun, Zhiying Zhao, Yi-Ping Li, Jian Tang, Ying Shen, Jian Wang
Rok vydání:	2019
Předmět:	Male Curcumin Drug Compounding Drug Evaluation Preclinical Pharmaceutical Science Administration Oral Biological Availability 02 engineering and technology Poloxamer Mixed micelle 030226 pharmacology & pharmacy Micelle Permeability Polyethylene Glycols Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Drug Discovery Animals Humans Vitamin E Solubility Intestinal Mucosa Micelles Pharmacology Drug Carriers Chemistry Organic Chemistry Anti-Inflammatory Agents Non-Steroidal Reflux 021001 nanoscience & nanotechnology Bioavailability Rats Drug Liberation Intestinal Absorption Models Animal Gastroesophageal Reflux Caco-2 Cells 0210 nano-technology Stearic Acids Nuclear chemistry
Zdroj:	Drug development and industrial pharmacy. 45(9)
ISSN:	1520-5762
Popis:	The aim of this study was to improve the solubility, oral bioavailability, and anti-gastroesophageal reflux activity of curcumin (CM) by preparing two CM-loaded, novel, binary mixed micelles (CM-M). The two CM-M were prepared by ethanol thin-film hydration method. One (CM-T) was prepared using D-alpha-tocopheryl polyethylene glycol 1000 succinate and Solutol
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0dd7e2026d44bed0188d718c3eec03 https://pubmed.ncbi.nlm.nih.gov/31170849 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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