Evidence for a mouse pathogenicity locus in certain temperature-sensitive mutants of foot-and-mouth disease virus
| Autor: | J Y Richmond |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Immunology
Mutant Virulence Locus (genetics) Virus Replication Microbiology Mice Tissue culture Aphthovirus Culture Techniques Animals Gene Genetics biology Temperature biology.organism_classification Virology Infectious Diseases Genes Viral replication Mutation Cattle Parasitology Foot-and-mouth disease virus Research Article |
| Zdroj: | Infection and Immunity. 16:827-831 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.16.3.827-831.1977 |
| Popis: | Serial tissue culture passaging of three foot-and-mouth disease temperature-sensitive mutants demonstrated the stability of their temperature sensitivity and mouse avirulence characteristics. Recovery of mouse-virulent temperature-sensitive viruses after passage of the mutants in mice suggested that these were not covariant expressions of the same locus, but were under the control of different genes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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