Prevalence and interaction of malaria and helminth co-infections among symptomatic and asymptomatic children in Southwest Nigeria
| Autor: | George O. Ademowo, Ayokulehin M. Kosoko, Ganiyu O. Arinola, H O Dada-Adegbola, Catherine O. Falade, Olawunmi R Rabiu |
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| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty business.industry Lamivudine Renal function Lopinavir General Medicine Gastroenterology Asymptomatic lcsh:Infectious and parasitic diseases Atazanavir Surgery Regimen Infectious Diseases Internal medicine medicine lcsh:RC109-216 Ritonavir medicine.symptom business Didanosine medicine.drug |
| Zdroj: | International Journal of Infectious Diseases, Vol 21, Iss S1, p 297 (2014) |
| ISSN: | 1201-9712 |
| DOI: | 10.1016/j.ijid.2014.03.1035 |
| Popis: | spine bone mineral density(BMD) were performed at baseline and week 48. Results: Fifty-eight% were female. The median(IQR) age was 13.6(11.9–14.7) years, body weight was 34.9(30.5–39.7) kg and CD4 was 670(540–1233)cells/mm3. At screening, 17 children used lopinavir/ritonavir-based regimen with lamivudine(82%), zidovudine(47%), didanosine(41%), and TDF(18%) and 2 were PI-naive. At week 48, median CD4was 710(557-1051) cells/mm3 (p=0.8). HIV-RNA 2mg/dL (p=0.03). Proportion of children with creatinine clearance by Schwartz formula 130mg/dL declined from 53% to 21% (p=0.03). The other lipid markers were unchanged. Lumbar spine BMD Z-score at baseline was -1.40 (0.93) and at week 48was 0.72 (0.10) (p=0.1). Proportion with lumbar spine BMD Z-score< 1.5 at baseline vs. week 48 was 56% vs. 68% (p=0.50). Proportion with lumbar spine BMD Z-score< -2.0 at baseline vs. week 48 was 25% vs. 44% (p=0.25). Conclusion: Second-line atazanavir/ritonavir 200/100mg with TDF and lamivudine was effective. However, the clinical impact of the total bilirubin rise and the creatinine clearance decline requires long-term monitoring. |
| Databáze: | OpenAIRE |
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