Pharmacological Approach to Diabetic Macular Edema
| Autor: | Giuseppe Casalino, Anat Loewenstein, Michaella Goldstein, M. Battaglia Parodi, Francesco Bandello, D. Pelayes |
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| Přispěvatelé: | Bandello, Francesco, Casalino, G, Loewenstein, A, Goldstein, M, Pelayes, D, Parodi, Mb |
| Rok vydání: | 2013 |
| Předmět: |
Vascular Endothelial Growth Factor A
medicine.medical_specialty Visual acuity Standard of care genetic structures Combination therapy Diabetic macular edema Angiogenesis Inhibitors Macular Edema Cellular and Molecular Neuroscience medicine Humans Intensive care medicine Glucocorticoids Drug Implants Anti vegf Diabetic Retinopathy Laser Coagulation business.industry Laser treatment General Medicine Combined Modality Therapy eye diseases Sensory Systems Surgery Clinical trial Ophthalmology Treatment Outcome Delayed-Action Preparations Intravitreal Injections medicine.symptom business |
| Zdroj: | Ophthalmic Research. 51:88-95 |
| ISSN: | 1423-0259 0030-3747 |
| DOI: | 10.1159/000356693 |
| Popis: | Diabetic macular edema (DME) is a highly prevalent cause of vision loss and has a remarkable impact on public health, and on the quality of life of diabetic patients. Even though laser photocoagulation has been the standard of care for decades, a substantial group of patients are unresponsive and fail to improve after laser treatment. Recently, new pharmacological approaches based on the use of intravitreal drugs, such as corticosteroids and anti-vascular endothelial growth factor, have revolutionized the treatment of DME. The use of intravitreal drugs is supported by the improvement in visual acuity reported by several clinical trials and can limit the potentially destructive effects of the laser treatment. Encouraging results also emerged from studies evaluating the use of a combination therapy, or the association of intravitreal drugs and laser treatment. This review aims at providing a brief synopsis of the main investigations regarding the current pharmacological approach to DME. (C) 2013 S. Karger AG, Basel |
| Databáze: | OpenAIRE |
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