Alkylation of DNA and proteins in mice exposed to vinyl chloride
| Autor: | Dan Hultmark, Carl Axel Wachtmeister, C.J. Calleman, Lars Ehrenberg, R. Göthe, D. Segerbäck, Siv Osterman-Golkar |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
Vinyl Compounds Alkylation Kinetics Vinyl Chloride Biophysics medicine.disease_cause Biochemistry Vinyl chloride Hemoglobins Mice chemistry.chemical_compound Nucleophile Testis medicine Animals Organic chemistry Amino Acids Molecular Biology chemistry.chemical_classification Proteins DNA Cell Biology Metabolism Amino acid Liver chemistry Carcinogenesis |
| Zdroj: | Biochemical and Biophysical Research Communications. 76:259-266 |
| ISSN: | 0006-291X |
| Popis: | Experiments with mice show that the pre-carcinogen vinyl chloride is metabolically converted to a short-lived alkylating intermediate which introduces the 2-oxoethyl group onto nucleophilic sites in DNA and proteins. The absolute and relative amounts of alkylated products support the hypothesis that the main reactive metabolite is chloroethylene oxide. |
| Databáze: | OpenAIRE |
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