Regression of Left Ventricular Hypertrophy in Patients with Essential Hypertension: Outcome of 12 Years Antihypertensive Treatment
| Autor: | Motoyoshi Tsujino, Nobuyuki Takasu, Satoshi Shigematsu, Toru Aizawa, Zenji Shimizu, Takashi Yamada, Akihiro Niwa, Yasuhiro Miyahara, Kunihide Hiramatsu |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Sodium Chloride Symporter Inhibitors Adrenergic beta-Antagonists Cardiomegaly Benzothiadiazines Left ventricular hypertrophy Essential hypertension Muscle hypertrophy Electrocardiography Nifedipine Internal medicine medicine Humans Pharmacology (medical) Methyldopa Myocardial infarction Diuretics Antihypertensive Agents Thiazide Aged business.industry Middle Aged medicine.disease Blood pressure Echocardiography Hypertension Cardiology Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Cardiology. 77:280-286 |
| ISSN: | 1421-9751 0008-6312 |
| Popis: | To assess the regression of cardiac hypertrophy during long-term (12 years) antihypertensive treatment, the following parameters were determined in 93 patients with essential hypertension: SV1 + RV5 by electrocardiography (ECG), and septal wall (SW) and posterior wall (PW) thickness by echocardiography (UCG). The patients were treated with a thiazide diuretic alone (group 1), thiazide + beta-blocker (group 2), thiazide + methyldopa or nifedipine (group 3) or nifedipine or methyldopa alone (group 4). The blood pressure decreased gradually within 6 months of treatment. According to ECG, regression of left ventricular hypertrophy occurred during the initial 7 years in all groups, whereas in the subsequent 5 years, statistically significant regression was found only in the patients treated with thiazide + other drugs (group 3). By UCG, which was taken only at the 7th and 12th year, regression was detectable during the last 5 years in all groups. The apparent incidence of regression of hypertrophy was lower in the thiazide-alone group (group 1) than in the thiazide + beta-blocker group (group 2), most likely due to mild hypertension in group 1. A cardiovascular accident (nonfatal myocardial infarction) occurred only in 1 patient. We conclude that during long-term antihypertensive treatment, persistent, progressive reversal of cardiac hypertrophy takes place. |
| Databáze: | OpenAIRE |
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