Lactose drives Enterococcus expansion to promote graft-versus-host disease

Autor:	Ying Taur, Lauren Bohannon, Sean M. Devlin, Daniela Weber, M. A. Jamal, Koji Hayasaka, Melissa D. Docampo, Emily Fontana, D. Pham, Nelson J. Chao, Daigo Hashimoto, Jonathan U. Peled, R. Pinedo, Meagan V. Lew, Joao B. Xavier, Eric G. Pamer, C. Scheid, Anna Staffas, C. K. Stein-Thoeringer, Sergio Giralt, D. Bajic, Molly Maloy, Luigi A Amoretti, G. Armijo, Yusuke Shono, Anthony D. Sung, A. Lazrak, Yuta Hasegawa, Roberta J. Wright, Alessandro Pastore, M. Burgos da Silva, A. Tsakmaklis, J. B. Slingerland, Robert R. Jenq, Ernst Holler, M. E. Arcila, Doris M. Ponce, Kate A. Markey, Annelie Clurman, Julia A. Messina, Antonio L.C. Gomes, Ann E. Slingerland, Eric R. Littmann, M.R.M. van den Brink, Amy Bush, Sebastien Monette, Miguel-Angel Perales, Takanori Teshima, Amanda J. Pickard, Kristi Romero, M. J. G. T. Vehreschild, K. B. Nichols, Justin R. Cross
Rok vydání:	2019
Předmět:	Male medicine.medical_treatment Graft vs Host Disease Lactose Disease Hematopoietic stem cell transplantation Article Feces Mice chemistry.chemical_compound RNA Ribosomal 16S Genotype medicine Animals Transplantation Homologous Humans Aged Drive Multidisciplinary Bacteria biology Sequence Analysis RNA business.industry Microbiota Hematopoietic Stem Cell Transplantation Middle Aged biology.organism_classification medicine.disease Gastrointestinal Microbiome Intestines Transplantation surgical procedures operative Graft-versus-host disease Enterococcus chemistry Immunology Dysbiosis Female business
Zdroj:	Science
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.aax3760
Popis:	Lactose can fuel GVHD Allogeneic hematopoietic cell transplantation (allo-HCT) is used to treat certain hematopoietic malignancies, but patients have a risk of developing graft-versus-host disease (GVHD). Stein-Thoeringer et al. performed a large-scale analysis of more than 1300 patients treated with allo-HCT across four clinical centers (see the Perspective by Zitvogel and Kroemer). High levels of bacteria from the Enterococcus genus were associated with greater incidence of GVHD and mortality. Lactose appears to provide a substrate for Enterococcus growth, and patients with a lactose-malabsorption genotype had a greater abundance of Enterococcus. A lactose-free diet limited Enterococcus growth, reduced the severity of GVHD, and improved survival in gnotobiotic mouse models. Science , this issue p. 1143 ; see also p. 1077
Databáze:	OpenAIRE
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