Structure, evolution and expression of the FOXL2 transcription unit
| Autor: | Xuhua Xia, Julie Cocquet, E. De Baere, M. Gareil, M. Fellous, Reiner A. Veitia, Maëlle Pannetier |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Forkhead Box Protein L2
Transcription Genetic Sequence analysis Molecular Sequence Data Biology Polyadenylation FOXL2 Gene Evolution Molecular Negative selection Mice Transcription (biology) Genetics medicine Medicine and Health Sciences Animals Humans Amino Acid Sequence RNA Messenger Molecular Biology Transcription factor Genetics (clinical) Conserved Sequence Forkhead Transcription Factors medicine.disease Premature ovarian failure DNA-Binding Proteins Open reading frame Forkhead box L2 Female Sequence Alignment Transcription Factors |
| Zdroj: | CYTOGENETIC AND GENOME RESEARCH |
| ISSN: | 1424-8581 |
| Popis: | FOXL2 is a putative transcription factor involved in ovarian development and function. Its mutations in humans are responsible for the blepharophimosis syndrome, characterized by eyelid malformations and premature ovarian failure (POF). Here we have performed a comparative sequence analysis of FOXL2 sequences of ten vertebrate species. We demonstrate that the entire open reading frame (ORF) is under purifying selection leading to strong protein conservation. We also review recent data on FOXL2 transcript and protein expression. FOXL2 has been shown 1) to be the earliest known sex dimorphic marker of ovarian determination/differentiation in vertebrates, 2) to have, at least in mammals, an ovarian expression persisting until adulthood. The conservation of its sequence and pattern of expression suggests that FOXL2 might be a key factor in the early development of the vertebrate female gonad and involved later in adult ovarian function. Finally, we provide arguments for the existence of an alternative transcript in rodents, that may arise from a differential polyadenylation. Although it has only been demonstrated in rodents, its presence/absence in other species deserves further investigation. |
| Databáze: | OpenAIRE |
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