Sea cucumbers-saponin ameliorates hepatorenal toxicity induced by Gentamicin in rats
| Autor: | Emad Elzayat, Mohamed Abdelmohsen Gamal, Ayman Saber Mohamed, Howayda Suliman |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Creatinine Antioxidant business.industry Holothuria Arenicola Saponin Gentamycin Hepatorenal toxicity Oxidative stress medicine.medical_treatment Glutathione Pharmacology medicine.disease_cause chemistry.chemical_compound chemistry Toxicity Medicine Uric acid Gentamicin business medicine.drug |
| Zdroj: | GSC Biological and Pharmaceutical Sciences. 14:129-136 |
| ISSN: | 2581-3250 |
| DOI: | 10.30574/gscbps.2021.14.3.0069 |
| Popis: | Background: Sea cucumbers have number of one of a pharmacological effects counting anticancer, anticoagulant, anti-inflammatory, antioxidant, and wound healing. Biological properties and therapeutic benefits of Sea cucumbers can be connected to the presence of a wide cluster of bioactive compounds particularly triterpene glycosides (saponins). Aims: The present study aimed to explore the hepatoprotective and nephroprotective activity of Sea cucumbers-saponin (Sc-S) on gentamicin-induced hepatorenal toxicity in rats. Main methods: Eighteen male Wistar rats were divided into three groups, control, gentamycin, and gentamycin+ Sc-S. The hepatorenal toxicity model was induced by gentamycin (80 mg/kg, i.p) for 8 days. Results: The Sc-S group showed a reduction in the concentrations of urea, uric acid, creatinine, MDA and the activities of AST, ALT, and ALP. While it caused a general increase in the levels of CAT and GSH. Microscopic examination appeared a clear enhancement in liver and kidney histology of Sc-S group. Conclusion: The antioxidant activity of Sc-S is the main mechanism for the protection of the liver and kidney against gentamicin toxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|