Neutrophil Extracellular Traps in Fatal COVID-19-Associated Lung Injury
Autor: | Astrid Obermayer, Lisa-Maria Jakob, Jasmin D. Haslbauer, Walter Stoiber, Matthias S. Matter, Alexandar Tzankov |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
0301 basic medicine ARDS Extracellular Traps Pathology medicine.medical_specialty Medicine (General) Article Subject Neutrophils Clinical Biochemistry Lung injury GPI-Linked Proteins 03 medical and health sciences 0302 clinical medicine R5-920 Antigens CD Genetics Humans Medicine Diffuse alveolar damage Lung Molecular Biology Aged Peroxidase Aged 80 and over biology business.industry Biochemistry (medical) COVID-19 Lung Injury General Medicine Neutrophil extracellular traps medicine.disease Immunohistochemistry 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Myeloperoxidase biology.protein Female Autopsy business Cytokine storm Cell Adhesion Molecules Research Article |
Zdroj: | Disease Markers, Vol 2021 (2021) Disease Markers |
ISSN: | 0278-0240 |
DOI: | 10.1155/2021/5566826 |
Popis: | An excess formation of neutrophil extracellular traps (NETs), previously shown to be strongly associated with cytokine storm and acute respiratory distress syndrome (ARDS) with prevalent endothelial dysfunction and thrombosis, has been postulated to be a central factor influencing the pathophysiology and clinical presentation of severe COVID-19. A growing number of serological and morphological evidence has added to this assumption, also in regard to potential treatment options. In this study, we used immunohistochemistry and histochemistry to trace NETs and their molecular markers in autopsy lung tissue from seven COVID-19 patients. Quantification of key immunomorphological features enabled comparison with non-COVID-19 diffuse alveolar damage. Our results strengthen and extend recent findings, confirming that NETs are abundantly present in seriously damaged COVID-19 lung tissue, especially in association with microthrombi of the alveolar capillaries. In addition, we provide evidence that low-density neutrophils (LDNs), which are especially prone to NETosis, contribute substantially to COVID-19-associated lung damage in general and vascular blockages in particular. |
Databáze: | OpenAIRE |
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