Female sexual hormones influence motor behaviour in rats after lesion of the entopeduncular nucleus
| Autor: | René Boucher, Jana Dankova, Pierre Langelier, Paul J. Bédard |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Apomorphine Motility Motor Activity Biology Promegestone Receptors Dopamine Lesion Internal medicine Basal ganglia medicine Animals Drug Interactions Castration Receptor Brain Mapping Estradiol General Neuroscience Ovary Corpus Striatum Rats Sexual hormones Endocrinology Female medicine.symptom Entopeduncular nucleus Hormone medicine.drug |
| Zdroj: | Neuroscience Letters. 17:89-94 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(80)90067-1 |
| Popis: | In rats bearing a unilateral lesion of the entopeduncular nucleus, female sexual hormones administered daily for fifteen days can decrease the rate o circling and the motility counts recorded after an injection of apomorphine 0.5 mg/kg, s.c. This suggests that female hormones can decrease the response to dopaminergic agonists in the basal ganglia possibly by affecting the sensitivity of the receptors. This may have interesting clinical applications especially in Parkinson's disease and tardive dyskinesias. |
| Databáze: | OpenAIRE |
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