Comparison of masseter muscle referred sensations after mechanical and glutamate stimulation: a randomized, double-blind, controlled, cross-over study
| Autor: | Gen Udagawa, Peter Svensson, Fernando G Exposto, Takuya Naganawa |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Pain Threshold Musculoskeletal pain medicine.medical_specialty Sensation Glutamic Acid Stimulation Audiology Stimulus (physiology) Masseter muscle Double blind Young Adult 03 medical and health sciences 0302 clinical medicine Double-Blind Method Physical Stimulation Excitatory Amino Acid Agonists Pressure Humans Medicine Referral and Consultation Cross-Over Studies Masseter Muscle business.industry Glutamate receptor 030206 dentistry Middle Aged Crossover study Healthy Volunteers Anesthesiology and Pain Medicine Neurology Female Neurology (clinical) business Head Craniofacial pain 030217 neurology & neurosurgery Gravitation |
| Zdroj: | Exposto, F, Udagawa, G, Naganawa, T & Svensson, P 2018, ' Comparison of masseter muscle referred sensations after mechanical and glutamate stimulation: a randomized, double-blind, controlled, cross-over study. ', Pain, vol. 159, no. 12, pp. 2649-2657 . https://doi.org/10.1097/j.pain.0000000000001379 |
| ISSN: | 1872-6623 0304-3959 |
| DOI: | 10.1097/j.pain.0000000000001379 |
| Popis: | Referred sensations (RS) are commonly found in various musculoskeletal pain conditions. Experimental studies have shown that RS can be elicited through glutamate injection and mechanical stimulation. Despite this, differences and similarities between these modalities in RS outcomes remain unclear. The aim of this study was to assess differences between mechanical-induced and glutamate injection-induced RS in the trigeminal region. The present randomized, double-blind, controlled, cross-over study recruited 60 healthy participants who were assessed in 2 different sessions. In both sessions, pressure was applied to the masseter muscle with 4 different forces (0.5, 1, 2, and 4 kg), and glutamate (1 mol/L or 0.25 mol/L) was injected into the same area. Participants rated their perceived masseter sensations and rated and drew any RS they experienced. No difference was found in number of participants reporting RS after glutamate injection compared with mechanical stimulation. More participants reported RS when the stimulus was painful compared with a nonpainful stimulus. Furthermore, it was shown that the more intense the stimulus, the higher the frequency of RS. Finally, RS centre-of-gravity location was similar between the 2 sessions. In summary, RS was elicited in healthy individuals through both modalities, and no differences in frequency of RS were observed in the orofacial region. Hence, RS does not seem to be modality-dependent, and only the painfulness of the stimulus caused an increase in frequency of RS. Finally, RS location for each participant was similar in both sessions possibly indicating a preferred location of referral. These findings may have implications for our understanding of RS in craniofacial pain conditions. |
| Databáze: | OpenAIRE |
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